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Moreover, infecting the Spodoptera frugiperda cell line with a baculovirus containing the G -isoform of pezo-1 (among the longest isoforms) demonstrates that pezo-1 encodes a mechanosensitive channel. elegans embryo cultures, we determine that pezo-1 KO cells do not display mechanosensitive currents, whereas cells expressing wild-type or GOF PEZO-1 exhibit mechanosensitivity. Using pressure-clamp experiments in primary C. Knockout (KO) and gain-of-function (GOF) mutants reveal that pezo-1 is involved in fine-tuning pharyngeal pumping frequency, as well as sensing osmolarity and food mechanical properties. Here, we leverage genome editing, genetics, microfluidics, and electropharyngeogram recording to establish that pezo-1 is expressed in the pharynx, including in a proprioceptive-like neuron, and regulates pharyngeal function. Whether pezo-1 encodes a mechanosensitive ion channel and contributes to pharyngeal function remains unknown. elegans alimentary canal, whose contraction and relaxation are modulated by mechanical stimulation elicited by food content. This myogenic pump is an essential component of the C.
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The Caenorhabditis elegans genome encodes an orthologue gene of the Piezo family, pezo-1, which is expressed in several tissues, including the pharynx.
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PIEZO channels are force sensors essential for physiological processes, including baroreception and proprioception.